Development and Characterization of Proteasome Inhibitors

Kim K. B., Fonseca F. N., Crews C. M. (2005) Methods in Enzymology 399: 585-609.

Although many proteasome inhibitors have been either synthesized or identified from natural sources, the development of more sophisticated, selective proteasome inhibitors is important for a detailed understanding of proteasome function. We have found that antitumor natural product epoxomicin and eponemycin...

Development and Characterization of Proteasome Inhibitors
Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation

Schneekloth J. S., Fonseca F. N., et al. (2004) Journal of the American Chemical Society 126: 3748-3754.

Genetic loss of function analysis is a powerful method for the study of protein function. However, some cell biological questions are difficult to address using traditional genetic strategies often due to the lack of appropriate genetic model systems. Here, we present a general strategy for the design and syntheses of...

Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation

PROTEASOME MODULATION